The Electrophysiology Research Foundation is a charitable organization incorporated on August 2, 1982. The Foundation is a non-profit corporation, organized and operated exclusively for charitable purposes.
FINISHED TRIALS
Finished Trials
Principal Investigator, Efficacy and Safety of Oral Cienzoline in sustained ventricular tachycardia>, Hoffman LaRoche, 1982
Principal Investigator, Comparative efficacy and safety of roal cibenzoline and quinidine in ventricular arrhythmias, Hoffman LaRoche, 1983
Principal Investigator, Efficacy and safety of intravenous tocainide in ventricular arrhythmias afer acute myocardial infarction, 1983-84
Principal Investigator, Efficacy of intravenous tocainide and lidocaine in ventricular arrhythmias, Merch Sharpe and Dohme, 1983-84
Principal Investigator, Efficacy of Intravenous and Oral nadolol in supraventricular tachycardia, Squibb Inc, 1983-84
Principal Investigator, Intravenous mexiletine in supraventricular tacycardia, Boehringer Ingelheim, 1983-84
Principal Investigator, Efficacy and safety of a double blind comparison of LYB5837 and Quinidine oin ventricular arrhythmias, Eli-Lilly, 1984
Co-Principal investigator, Electrophysiologic studies in diseased human ventricle in patients with sustained ventricular tachycardia, American Heart Association, New Jersey, 1983-84
Principal investigator, Long term efficacy of oral indecainide in ventricular tachycardia, Eli-Lilly, 1984
Prinicipal Investigator, Efficacy of oral propafenone in ventricular arrhythmias, Knoll Pharmaceuticals, 1984
Efficacy of Cordias Omni Orthocor I in Refractory Tachycardias, Cordis Corp, 1981
Principal Investigator, Efficacy of Cordis Omni Orthocor II in Refractory Tachyarrhythmias, Cordis, 1985
Principal Investigator, Effiacy of Intracavitary Cardioversion using Medtronic 5350 external cardioverter-defibrillator, Medtronic Inc.,1984
Investigator, Automatic Implantable Cardioverter Defibrillator, Intec, 1983
Comparative efficacy of sotalol versus placebo using a randomized crossover double blind study, Bristo, Myers, 1984
Principal Investigator, Comparative efficacy of milrinone, digoxin and placebo in congestive heart failure, Mead Johnson –Sterling Winthrop 1985-1987
Prinicipal Investigator, Effiacy of intravenous atenolol in supraventricular tachycardia, ICI Pharmaceuticals, 1985-86
Prinicipal Investigator, Efficacy of oral xamoterol in congestive heart failure, 1985-1987
Principal Investigator, Comparative efficacy of oral mexiletine and quinidine in sustained ventricular tachycardia, Boehringer-Ingelheim, 1986-87
Principal Investigator, Long term control of ventricular arrhythmias with oral sotalol, Bristol Myers Squibb,1985
Principal investigator, Effiacy of sequential pulse defibrillation, Medtronic Inc.,1987-89
Principal Investigator, Efficacy of intravenous and oral nadolol in sustained ventricular tachycardia, Squibb, 1986-87
Principal Investigator, Effiacacy of intravenous and oral recainam in sustained ventricular tachycardia, Wyeth Ayerst, 1987-88
Co- Prinicpal Investigator, Electrophysiologic Study Versus Electrocardiographic Monitoring, RO 1 Grant, NHLBI 1987-1992
Prinicipal Investigator, Efficacy of intravenous diltiazem in supraventricular tachycardia, Marion Labs,1988-1990
Principal investigator, Comparative efficacy of oral recainam and encainide in sustained ventricular tachycardia, Wyetgh Ayerst, 1988
Prinicipal Investigator, Telectronics Meta Pulse Generator, 1988
Principal investigator, Efficacy of oral propafenone in supraventricular tachycardia, Knoll Pharmaceuticals, 1988
Principal Investigator, Effficacy of oral diprafenone in ventricular tachycardia, Berlex Labs, 1988
Principal investigator, Ventricular Defibrillation with simultaneous transvenous shocks using monophasic and biphasic shocks with the Medtronic 5350 external cardioverter-defibrillator, Medtronic Inc., 1990-91
Principal investigator, Medtronic Ventricular Defibrillation study on simultaneous transvenous defibrillation using an optimal thoracic patch lead location, Medtronic Inc.,1990-1992
Co-Principal investigator, Multicenter Automatic Implantable Cardioverter Defibrillator Trial 1, University of Rochester and Guidant Corp., 1990-1995
Co-Principal Investigator, PCD Study, Medtronic Inc., 1990-1993
Co-Principal Investigator, Intermedics Res-Q implantable cardioverter-defibrillator, Intermedics, 1995
Planning and Steering Committee member and Co-Prinicipal Investigator, Antiarrhythmics versus Implantable Defibrillator Trial, National Institutes of Health, 1994-1998
Atrial Defibrillation using the Medtronic 5350 external cardioverter-defibrillator, Medtronic Inc. 1995-97
Prinicipal Investigator, Dual Site Atrial Pacing for Prevention of Atrial Fibrillation, Pilot and Main trials, Medtronic Inc., 1994-2000
Principal Investigator, Medtronic Jewel AF clinical trial in atrial fibrillation, Medtronic Inc., 1997-2000
Planning and Steering Committee member and Co-Prinicipal Investigator, AFFIRM Trial, National Institutes of Health, 1997-2002
Co-Principal Investigator, Multicenter Automatic Implantable Defibrillator Trial II, University of Rochester and Guidant Corp.,1998-2002
Co-Prinicipal Investigator, Triggers of Ventricular Arrhythmias (TOVA) Study, NHLBI, 2000-2002
Principal Investigator, Linear Radiofrequency ablation of the Right Atrium in Paroxysmal Atrial Fibrillation, Cardima Inc., 2000-2002
Principal Investigator, Multicenter Alternans Before Cardioverter Defibrillator (ABCD) Clinical Trial, 2002
Principal Investigator, Natural History of AF study, Medtronic Inc., 2000 – 2003
Principal Investigator, Biotronik Home Monitoring Trial, 2002 – 2005
Prinicipal Investigator, Procter & Gamble SHIELD study, 2001 – 2003.
Principal Investigator, Biotronik Option Study 2004 – 2007
Principal Investigator, Long-Term Azimilide Study 2003 – 2005
National Heart Lung and Blood Institute, NIH: TOPCAT trial – Steering committee member and co-investigator, 2005- present
The TOPCAT study is a multi-centered, international, randomized, double blind placebo-controlled study of the aldosterone antagonist spironolactone. The study is focused to evaluate 4500 adults with heart failure and left ventricular ejection fraction of at least 45%. These patients are recruited from over 150 clinical study centers. The trial is sponsored by the National Heart, Lung, and Blood Institute of the National Institutes of Health (NIH).
Link: http://www.topcatstudy.com/
Study Chair, Intracardiac Echocardiography Guided Cardioversion Helps Interventional Procedures (ICE-CHIP) study 2005 – present
The ICE-CHIP study is a sequential Phase I and Phase II pilot study comparing the cardiac imaging capabilities of intracardiac echocardiography (ICE) with with transesophageal echocardiography (TEE) followed by a randomized comparison of ICE guided cardioversion with a conventional cardioversion strategy in patients with atrial fibrillation. The composite incidence rate of major cardiac and bleeding complications (stroke, TIA, peripheral embolism, major hemorrhagic event) will be compared between the two treatment groups over the duration of the study.
Study Chair, Hybrid Therapy In Prevention of Atrial Fibrillation (HIPPAF) study, 2006 – present
Study Chair, Intracardiac Echocardiography Guided Cardiac Resynchronization Therapy in Heart Failure (ICE CRT-HF) study 2006 – present
Investigator, Mulitcenter Aryx Study on New Class 3 Antiarrhythmic Agent in Paced Patients with Atrial Atrial Fibrillation 2006 – present
The purpose of the Aryx study is to determine the safety and efficacy of an investigational antiarrhythmic drug. This drug will be used in the treatment of atrial fibrillation in patients with a double chamber pacemaker.
Link: http://www.clinicaltrials.gov/ct/show/NCT00389792?order=2
DR. SAKSENA’S ABSTRACTS & PRESENTATIONS
Manchanda SC, Guha SK, Tandon R, Saksena S, Talwar I: Electrical field plethysmography. Studies in cardiac disease. Presented, 2nd All India Seminar on Bio-Control Systems, Madras, India, 1972.
Roy SB, Manchanda SC, Saksena S: Circulatory and ventilatory effects of high altitudes on the performance of Indian soldiers. Presented, Indian Council of Medical Research, 1974.
Manchanda SC, Sharma R, Saksena S, Roy SB: Cardiac performance during maximal exercise at high altitude. Presented, Annual Meeting of Association of Physicians of India and the Cardiological Society of India, 1976.
Manchanda SC, Saksena S, Roy SB, Guha SK: Transthoracic electrical impedance: A simple bedside technique to monitor pulmonary edema. Presented, Intl Symp on Biomedical Engineering, New Delhi, India, 1978.
1980
Saksena S, Manchanda SC, Roy SB: Reduced physical work capacity at high altitude: The role of left ventricular dysfunction. Clin Res 1980;28:208A.
Saksena S, Manchanda SC, Roy SB: Cardiac performance at high altitude during maximal exercise. Proc VIIIth Eur Congr Cardiol 1980;1:211.
Saksena S, Garcia E, Fain J, Mallon SM, Myerburg RJ: Computerized regional wall motion analysis: Limitations of the right anterior oblique projection. Clin Res 1980;28:208A.
Juma Z, Saksena S, Raphan C, Sung RJ: Electrophysiological effects of N-acetyl procainamide (NAPA) in man. Clin Res 1980;28:184A.
Sung RJ, Saksena S, Juma Z, Waxman HL: Ventriculo-atrial conduction patterns in patients with dual atrioventricular nodal pathways. Proc VIIIth Eur Congr Cardiol 1980;1:213.
Juma Z, Saksnea S, Raphan C, Sung RJ: Pharmaco-electrophysiology of N-acetyl procainamide. Presented Annual Meeting, Canad Cardiovasc Soc, Winnipeg, 1980.
Juma Z, Saksena S, Levy S, Wolff GS, Sung RJ: Electrophysiologic characteristics of nodo-ventricular bypass tract conduction in patients with dual atrioventricular nodal pathways. Circulation 1980;62:III-47.
1981
Bernstein AD, Parsonnet V, Saksena S, Shilling E: Threshold curve approximations for pacemaker output programming. PACE 1981;4:A-33.
Parken P, Saksena S, Bernstein AD, Rodgers TK, Parsonnet V: Computer stimulation of complex cardiac arrhythmias: Preliminary evaluation of an electrophysiologic model. PACE 1981;4:A-242.
Parsonnet V, Shilling E, Saksena S, Malec R: How dangerous is sudden cessation of pacemaker function? PACE 1981;4:A-242.
Bernstein AD, Parsonnet V, Saksena S, Shilling E: Threshold curve approximations for pacemaker output programming. Presented, IInd Eur Symp on Cardiac Pacing, 1981.
Saksena S, Bernstein AD, Rathyen W, Smith JP, Parsonnet V: Epicardial and endocardial mapping in recurrent ventricular tachycardia: Preliminary evaluation of a microcomputer system. Chest 1981;80:385.
Saksena S, Parken P, Bernstein AD, Rodgers TK, Parsonnet V: A computer model for macro-reentrant cardiac dysrhythmias. Clin Res 1981;29:659A.
Saksena S, Bernstein AD, Rathyen W, Smith JP, Parsonnet V: A microcomputer system for cardiac mapping in recurrent ventricular tachycardia. Clin Res 1981;29:659A.
19. Saksena S: Limitations of current techniques for induction of ventricular tachycardia. Clin Res 1981;29:659A.
Bernstein AD, Saksena S, Rathyen W, Parsonnet V: Microcomputer system for serial cardiac potential mapping. Presented, Intl Conf Non-Invasive Techniques, Bombay, India, 1981.
Saksena S: Late electrophysiologic effects of oral amiodarone hydrochloride in refractory ventricular tachycardia. Presented, Intl Conf Non-Invasive Techniques, Bombay, India, 1981.
1982
Saksena S, Rothbart S, Kaufmann WE, Rathyen W: Chronic electrophysiologic, systemic and pharmacologic effects of amiodarone in recurrent ventricular tachycardia. Am J Cardiol 1982;49:1044.
Saksena S, Rothbart S, Cappello G. Pantopoulos D: Mechanisms and clinical implications of variant QRS patterns during right ventricular endocardial pacing. Clin Res 1982;30:678A.
Saksena S, Rothbart S, Cappello G: An analysis of prospective predictors of amiodarone efficacy in refractory ventricular tachycardia. Clin Res 1982;30:682A.
Saksena S, Rothbart S, Cappello G, Pantopoulos D, Bernstein A, Somani P: An appraisal of chronic lorcainide therapy in refractory ventricular tachycardia. Clin Res 1982;30:683A.
1983
Saksena S: Functional sinoatrial node disorders with dual atrioventricular nodal pathways. Clin Res 1983;31:215A.
Ferguson D, Saksena S, Greenberg E, Craelius W: Management of recurrent ventricular tachycardia: Economic impact of therapeutic alternatives. Clin Res 1983;31:296A.
Saksena S, Rothbart S, Craelius W, Cappello G, Pantopoulos D: Comparative pharmaco-electrophysiology of intravenous and oral amiodarone in refractory ventricular tachycardia. Clin Res 1983;31:254A.
Saksena S, Rothbart S, Craelius W, Cappello G, Pantopoulos D: Electrophysiologic and pharmacologic effects of continuous intravenous admiodarone infusion in refractory ventricular tachycarida. Clin Res 1983;31:250A.
Saksena S, Pantopoulos D, Rothbart S, Craelius W, Werres R: Mechanisms of left ventricular dysfunction during ventricular tachycardia and ventricular pacing in man. Clin Res 1983;31:216A.
Saksena S, Craelius W, Hussain SM, Parsonnet V: Intraoperative spectral analysis of ventricular electrograms during sinus rhythm and ventricular tachycardia. Clin Res 1983;31:216A.
Jacobs J, Saksena S, Rothbart S, Pantopoulos D: Value of programmed cardiac stimulation with acute drug testing in refractory supraventricular tachycardia. Clin Res 1983;31:194A.
Ferguson D, Saksena S, Greenberg E, Craelius W: Clinical and economic impact of electrophysiologic evaluation for ventricular tachycardia: A three-year study. PACE 1983;6:312.
Saksena S, Rothbart S, Cappello G, Pantopoulos D, Craelius W: Ventricular tachycardia induction during electrophysiologic studies: Role of the stimulation mode. PACE 1983;6:318.
Craelius W, Saksena S, Hussain SM, Pantopoulos D, Parsonnet V: Intraoperative spectral analysis of ventricular potentials during sinus rhythm and ventricular tachycardia. PACE 1983;6:321.
Saksena S, Rothbart S, Cappello G, Craelius W: Electrophysiologic and pharmacologic effects of continuous intravenous amiodarone infusion in refractory ventricular tachycardia. Clin Res 1983;31:692A.
Saksena S, Pantopoulos D, Rothbart S, Craelius W, Werres R: Mechanisms of left ventricular function during ventricular pacing and ventricular tachycardia in man. PACE 1983;6:A-105.
Saksena S, Craelius W, Hussain SM, Pantopoulos D, Parsonnet V: Intraoperative spectral analysis of ventricular electrograms during sinus rhythm and ventricular tachycardia. PACE 1983;6:A-116.
Saksena S: Functional sinoatrial node disorders. An association with dual atrioventricular nodal pathways. PACE 1983;6:A-116.
Jacobs J, Saksena S, Rothbart S: Role of electrophysiologic studies with acute drug testing in refractory supraventricular tachycardia. PACE 1983;6:A-126.
Ferguson D, Saksena S, Greenberg E, Craelius W: Management of ventricular tachycardia: Economic impact of therapeutic alternatives – A three-year study. PACE 1983;6:A-139.
Rothbart S, Saksena S, Craelius W, Cappello G, Pantopoulos D: Comparative pharmaco-electrophysiology ofintravenous and oral amiodarone in refractory ventricular tachycardia. PACE 1983;6:A-314.
Rothbart S, Saksena S, Hussain SM, Parsonnet V, Craelius W: ECG effects of endocardial resection: A comparative study. Clin Res 1983;31:215A.
Saksena S, Craelius W, Liptak K: Pharmaco-electrophysiology of mexiletine in refractory ventricular tachycardia. Clin Res 1983;31:672A.
Saksena S, Rothbart ST, Liptak K: Optimising amiodarone therapy for refractory ventricular tachycardia. Clin Res 1983;31:672A.
Craelius W, Levine RS, Saksena S, Hussain SM, Pantopoulos D, Rothbart S: A practical approach to epicardial mapping during open heart surgery. Trans Biomed Eng BME 1983;30:493.
1984
Saksena S, Ciccone J, Rothbart ST, Liptak K, Craelius W: Efficacy of transvenous cardioversion in ventricular tachycardia: A prospective randomized study. J Am Coll Cardiol 1984;3:554.
Craelius W, Saksena S, Pantopoulos D, Hussain SM, Parsonnet V, Gielchinsky I: Frequency analysis of cardiac potentials: A new technique for ventricular tachycardia detection. J Am Coll Cardiol 1984;3:581.
Craelius W, Saksena S, Pantopoulos D, Rothbart ST: Frequency characteristics of antegrade and retrograde human atrial potentials. J Am Coll 1984;Cardiol 3:582.
Saksena S, Parsonnet V, Pantopoulos D, Rothbart ST, Hussain SM, Gielchinsky I: Experience with an implantable antitachycardia system. Presented, 6th Intl Sem on Cardiac Arrhythmias, Trento, Italy, 1984.
Saksena S, Parsonnet V: Antitachycardia pacemaker systems. Symp on Physiol Pacing, Madrid, Spain, 1984.
Saksena S, Rothbart ST, Shah Y, Tranotti K: Chronic effects of oral cibenzoline in refractory ventricular tachycardia. Presented, Ann Meeting, Amer Soc Clin Pharmacol and Therapeutics, 1984.
Craelius W, Saksena S, Pantopoulos D, Rothbart ST: Frequency spectra of retrograde atrial potentials: Relationship to ventricular conduction patterns. Clin Res 1984;32:157A.
Rothbart ST, Saksena S: Exercise related ventricular tachycardia: The role of electrophysiologic studies. Clin Res 1984;32:201A.
Shah Y, Saksena S, Ciccone J, Rothbart ST, Tranotti K, Pantopoulos D: Factors influencing the efficacy of transvenous cardioversion for sustained ventricular tachycardia. Clin Res 1984;32:205A.
Shah Y, Saksena S, Ciccone J, Rothbart ST, Tranotti K: Determinants of success and failure during transvenous cardioversion for ventricular tachycardia. PACE 1984;7:464.
Saksena S, Pantopoulos D, Parsonnet V, Rothbart ST, Hussain SM, Gielchinsky I, Lombardo S: Clinical evaluation of an implantable antitachycardia system. PACE 1984;7:476.
Saksena S, Rothbart ST, Shah Y, Tranotti K: Chronic effects of oral cibenzoline in refractory ventricular tachycardia. PACE 1984;7:476.
Saksena S, Nanda NC, Rosenbloom M, Ciccone J, Craelius W, Rothbart ST: Hemodynamic and echocardiographic studies of left ventricular function during ventricular tachycardia. PACE 1984;7:477.
Saksena S, Craelius W, Pantopoulos D, Rothbart ST: Influence of ventriculo-atrial conduction patterns on frequency spectra of retrograde atrial potentials. PACE 1984;7:477.
Saksena S, Ciccone J, Rothbart ST, Liptak K, Craelius W: A prospective randomized study of transvenous cardioversion in ventricular tachycardia. Eur Ht J 1984;5:Suppl I-198.
Saksena S, Rothbart ST, Shah Y, Liptak K: Electropharmacologic effects of chronic oral cibenzoline in refractory ventricular tachycardia. Eur Ht J 1984;5:Suppl I-228.
Craelius W, Saksena S, Chen V, Rothbart S, Pantopoulos D: Spectral analysis of human arterial blood pressure. Clin Res 1984;32:157A.
Saksena S, Nanda NC, Rosenbloom M, Ciccone JM, Craelius W, Rothbart ST: Left ventricular function in ventricular tachycardia: Hemodynamic and echocardiographic studies. Clin Res 1984;32:203A.
Saksena S, Pantopoulos D, Parsonnet V, Rothbart ST, Hussain SM, Gielchinsky I, Lombardo S: The value of an implantable antitachycardia system in patients with recurrent sustained tachycardias. Clin Res 1984;32:203A.
Saksena S, Rothbart ST, Shah Y, Tranotti K: Efficacy and electropharmacology of oral cibenzoline in ventricular tachycardia. Clin Res 1984;32:203A.
Saksena S, Shah Y, Boccodamo R, Rothbart ST: Comparative efficacy of transvenous cardioversion and pacing in ventricular tachycardia: A prospective randomized crossover study. Circulation 1984;70:II-406.
Wasty N, Saksena S, Barr MJ: Comparative efficacy of oral cibenzoline and quinidine on ventricular arrhythmias: a prospective randomized crossover study. Circulation 1984;70:II-406.
1985
Saksena S, Ciccone J, Chandran P, Rothbart ST, Pantopoulos D, Lee B: Laser ablation of normal and diseased human ventricle. J Am Coll Cardiol 1985;5:473.
Saksena S, Goldberg W, Rothbart ST: The electropharmacology and long-term clinical efficacy of mexiletine in refractory ventricular tachycardia. J Am Coll Cardiol 1985;5:482.
Calvo R, Saksena S, Barr MJ: Electrophysiologic effects, efficacy and safety of oral moricizine hydrochloride in sustained ventricular tachycardia. J Clin Pharmacol Therapeu 1985;253:10.
Saksena S, Ciccone J, Chandran P, Pantopoulos D: Argon laser ablation of human ventricle: Dose-response studies in normal and diseased tissues. Presented, Intl Symp on Fulguration and Laser in Cardiac Arrhythmias, Paris, France, April 1985.
Ciccone J, Saksena S, Pantopoulos D: Continuous and pulsed argon laser ablation of human diseased ventricle – a comparative study. Clin Res 1985;33:175A.
Lavery D, Saksena S, Rothbart ST, Barr MJ: Long-term clinical efficacy of electrophysiologically-guided amiodarone therapy for refractory sustained ventricular tachycardia. Clin Res 1985;33:302A.
Rothbart S, Ciccone J, Saksena S: Transvenous cardioversion – Mechanisms of ventricular tachycardia termination and acceleration. PACE 1985;8:302.
Saksena S, Shah Y, Boccadomo R, Calvo R, Kowey P, Barr MJ, Olukotun O: Intravenous nadolol for refractory supraventricular tachycardia: Mechanisms, electropharmacology, efficacy and safety. PACE 1985;8:305.
Saksena S, Wasty N, Hussain SM, Gielchinsky I, Parsonnet V: Efficacy of subendocardial resection is related to the site of origin of ventricular tachycardia. PACE 1985;8:306.
Ciccone J, Saksena S, Pantopoulos D: Comparative efficacy of continuous and pulsed argon laser ablation of diseased human ventricle. PACE 1985;8:318.
Rothbart ST, Ciccone J, Saksena S: Mechanism of ventricular tachycardia termination and acceleration during transvenous cardioversion. PACE 1985;8(II):A-39.
80. Saksena S, Wasty N, Hussain SM, Gielchinsky I, Parsonnet V: Site of origin of ventricular tachycardia influences efficacy of subendocardial resection. PACE 1985;8(II):A-88.
Calvo R, Saksena S, Barr MJ: Clinical efficacy, electrophysiologic effects and safety of oral ethmozine in sustained ventricular tachycardia. PACE 1985;8(II):A-97.
Calvo R, Saksena S, Rothbart ST, Pantopoulos D: Efficacy and safety of a combined pacing and transvenous cardioversion algorithm in ventricular tachycardia: A prospective randomized study. Circulation 1985;72:III-383.
1986
Rothbart ST, Saksena S, Pantopoulos D, Calvo R: Efficacy and safety of transvenous cardioversion and rapid ventricular tachycardia using two energy waveforms: A prospective randomized study. J Am Coll Cardiol 1986;7:73A.
Gordon S, Lavery D, Calvo K, Saksena S: Doppler overestimation of systolic aortic valve gradient in patients with aortic regurgitation. J Am Coll Cardiol 1986;7:73A.
Saksena S, Rothbart ST, Calvo R, Pantopulos D, Hussain SM: Mechanism of efficacy of transvenous cardioversion of ventricular tachyarrhythmias as determined by cardiac mapping in man. J Am Coll Cardiol 1986;7:73A.
Lavery D, Saksena S, Gordon S, Rothbart ST, Barr MJ: Long-term efficacy of amiodarone therapy in refractory sustained ventricular tachycardia: The role of electrophysiologic studies and ambulatory monitoring. J Am Coll Cardiol 1986;7:91A.
Saksena S, Calvo RA, Rothbart ST, Pantopoulos D: High power rapid pulsed argon laser ablation of diseased human ventricle. PACE 1986;9:299.
Switzer D, Saksena S, Nanda N, Calvo R, Rothbart ST, Calvo K: Color and pulsed Doppler flow mapping of mitral blood flow during sustained ventricular tachycardia. PACE 1986;9:301.
Calvo RA, Saksena S, Pantopoulos D, Rothbart ST: Comparison of a single and two simultaneous transvenous shocks in rapid ventricular tachycardia. Clin Res 1986;34:287A.
Chandran P, Saksena S, Rothbart ST, Barr MJ: Electrophysiologically-guided treatment of sustained ventricular tachycardia: Evaluation of an algorithm incorporating pharmacologic, electrical and surgical therapy. Clin Res 1986;34:288A.
Gordon S, Lavery D, Calvo K, Saksena S: Noninvasive estimation of left ventricular end diastolic pressure by Doppler ultrasound in patients with aortic regurgitation. Clin Res 1986;34:304A.
Saksena S, Calvo RA, Gadhoke A, Pantopulos D: Comparison of continuous wave and high power pulsed argon laser ablation in diseased human ventricle. Clin Res 1986;34:340A.
Saksena S, Rothbart ST, Calvo RA, Pantopoulos D: Effects of varying laser power output on laser ablation of human diseased ventricle. Clin Res 1986;34:341A.
Saksena S, Rothbart ST: Acute hemodynamic effects of low and high energy intracardiac shocks for ventricular tachycardia cardioversion and arrhythmia ablation in man. Clin Res 1986;34:341A.
Saksena S, Calvo RA, Pantopoulos D, Gordon S, Gadhoke A: Simultaneous shocks for ventricular tachycardia cardioversion: Effect of electrode position on efficacy. Clin Res 1986;34:341A.
Saksena S, Calvo RA, Pantopoulos D, Rothbart ST, Gadhoke A: Cardioversion of rapid ventricular tachycardia with two simultaneous transvenous shocks in man. Clin Res 1986;34:341A.
Switzer D, Saksena S, Nanda N, Calvo RA, Rothbart ST, Calvo K: Color and pulsed Doppler flow mapping of mitral flow during sustained ventricular tachycardia. Clin Res 1986;34:347A.
Saksena S, Calvo RA, Pantopoulos D, Gordon S, Gadhoke A: Simultaneous shocks for ventricular tachycardia cardioversion: Effect of electrode position. Proc X World Congr of Cardiol, 1986;p 483.
Saksena S, Kesselbrenner M, Rothbart ST, Gadhoke A: Hemodynamic effects of low and high energy intracardiac shocks in man. Proc X World Congr of Cardiol, 1986;p 185.
Calvo R, Saksena S, Rothbart ST, Pantopoulos D, Gadhoke A: Comparison of a single and two simultaneous transvenous shocks in rapid ventricular tachycardia. Proc X World Congr of Cardiol, 1986;p 185.
Pantopoulos D, Calvo R, Rothbart S, Saksena S: Ventricular tachycardia termination with pacing and cardioversion, Presented, 3rd Natl Conf on Cardiac Pacing & Electrophysiol, New Delhi, India, Feb 1986.
Rothbart ST, Saksena S, Calvo RA, Pantopoulos D: Improved results with antitachycardia pacemakers for refractory ventricular tachycardia. Circulation 1986;74:II-184.
Saksena S, Hussain SM, Gielchinsky I, Gadhoke A, Pantopoulos D: Successful mapping-guided argon laser ablation of ventricular tachycardia in man. Circulation 1986;74:II-186.
Saksena S, Tarjan P, Bharati S, Boveja B, Cohen D, Joubert T: A new technique for successful low energy His bundle ablation using a suction electrode catheter. Circulation 1986;74:II-387.
Saksena S, Gadhoke, Pantopoulos D, Osypka P: Radiofrequency ablation of arrhythmogenic diseased human ventricle. Circulation 1986;74:II-461.
1987
Lindsay BD, Rothbart ST, Wasty N, Pantopoulos D, Saksena S: Prospective evaluation of ven tricular pacing and high energy transvenous shocks using a triple electrode array for cardioversion of ventricular tachycardia. J Am Coll Cardiol 1987;9:141A.
Wasty N, Pantopoulos D, Rothbart ST, Cohen L, Saksena S: Detection of sustained ventricular tachyarrhythmias using right ventricular hemodynamic parameters: A prospective study. J Am Coll Cardiol 1987;9:141A.
Wasty N, Saksena S, Parsonnet V, Hussain SM, Gielchinsky I, Shepherd M: Long-term efficacy and complications of antitachycardia pacemakers compared with implantable defibrillators. J Am Coll Cardiol 1987;9:143A.
Saksena S, Hussain SM, Gielchinsky I, Pantopoulos D, Wasty N, Rothbart ST, Alizadeh J: Intraoperative mapping-guided argon laser ablation of malignant supraventricular and ventricular tachycardia. J Am Coll Cardiol 1987;9:249A.
Saksena S, Rothbart ST, Gadhoke A, Hussain SM, Gielchinsky I: Anatomic, hemodynamic and electrophysiologic effects of argon laser endocardial ablation for refractory ventricular tachycardia in man. PACE 1987;10:411.
Saksena S, Furman R, Gadhoke A, Osypka P: Feasibility of radiofrequency ablation of supraventricular and ventricular tachyarrhythmias. PACE 1987;10:414.
Saksena S, Rothbart ST, Lindsay BD, Calvo RA, Pantopoulos D: Is there an optimal termination algorithm for transvenous cardioversion of ventricular tachycardia? PACE 1987;10:416.
Saksena S, Hussain SM, Gielchinsky I, Gadhoke A, Pantopoulos D: Laser ablation of human atrium and accessory pathways: Experimental observations and early clinical experience. PACE 1987;10:427.
Saksena S, Rothbart ST, Calvo RA, Pantopoulos D: Comparison of single and dual current pathways for transvenous cardioversion in rapid ventricular tachycardia. PACE 1987;10:446.
Calvo RA, Rothbart ST, Saksena S, Barr MJ, Gadhoke A: Improved efficacy with combined mexiletine/quinidine therapy in ventricular tachycardia. Clin Res 1987;35:265A.
Saksena S, Rothbart ST, Schwarz T, Barr MJ, Herman S: Combination therapy improves survival in patients with persistently inducible ventricular tachycardia on amidarone. Clin Res 1987;35:323A.
Gielchinsky I, Hussain SM, Saksena S: Clinical efficacy and safety of intraoperative mapping-guided laser endocardial ablation in patients with malignant supraventricular and ventricular tachycardia. PACE 1987;10(II):681.
Saksena S, Rothbart ST, Lindsay BD, Calvo RA, Pantopoulos D: Combined pacing and shock therapy for transvenous cardioversion of ventricular tachycardia. PACE 1987;10(I):607.
Saksena S, Rothbart ST, Lindsay BD, Calvo RA, Pantopoulos D: Selection of the optimal tachycardia termination mode: Comparison of two algorithms for transvenous cardioversion of ventricular tachycardia. PACE 1987;10(II):737.
Saksena S, Rothbart ST, Schwarz T, Barr MJ, Herman S: Outcome of combination therapy in patients with persistently inducible ventricular tachycardia on amiodarone. PACE 1987;10(II):737.
Saksena S, Calvo RA, Pantopoulos D, Rothbart ST: A prospective evaluation of single and dual current pathways for transvenous cardioversion in rapid ventricular tachycardia. PACE 1987;10(II):738.
Saksena S: Laser ablation for tachyarrhythmia control: Development and expectations. PACE 1987;10(II):1027.
Saksena S: Future developments for implantable cardioverters and defibrillators. PACE 1987;10(II):1041.
Saksena S, Lim F Jr, Prasher S, An HL: Feasibility of transcatheter argon laser ablation for ventricular tachyarrhythmias. Circulation 1987;76(II):IV-278.
Saksena S, Parsonnet V, Pantopoulos D, Rothbart ST: Transvenous cardioversion and defibrillation of ventricular tachyarrhythmias using bidirectional shocks: Acute feasibility studies and chronic device implantation. Circulation 1987;76(II):IV-311.
Steinberg JS, Freedman RA, for the ESVEM Investigators: The signal averaged ECG does not predict drug efficacy in sustained ventricular arrhythmias. Circulation 1987;76(II):IV-344.
Rothbart ST, Saksena S, Barr MJ: Chronic amiodarone therapy for refractory ventricular tachycardia: Improved patient survival and toxicity management with combination therapy – a five-year study. Circulation 1987;76(II):IV-367.
Saksena S, Rothbart ST, Barr MJ, Herman S, Munsif AN, Wasty N, Olukotun AY: Efficacy of nadolol alone or in combination with a type IA antiarrhythmic drug in sustained ventricular tachycardia: a prospective study. Circulation 1987;76(II):IV-511.
Milrinone Multicenter Trial Group: Oral milrinone and digoxin in heart failure: Results of a placebo controlled prospective trial of each agent and the combination. Circulation 1987;76(II):IV-256.
1988
An HL, Saksena S, Lim F Jr, Prasher S, Janssen M: Ventricular ablation with radiofrequency energy: Comparison of different catheter energy delivery systems. J Am Coll Cardiol 1988;11:17A.
Saksena S, An HL, Herman S, Marcantuono D: Clinical outcome of patients with intact atrioventricular conduction after atrioventricular junction ablation for refractory supraventricular tachyarrhythmias. J Am Coll Cardiol 1988;11:177A.
Saksena S, Munsif AN, Hussain SM, Gielchinsky I: Long-term clinical results of intraoperative mapping-guided argon laser ablation of malignant supraventricular and ventricular tachycardias. J Am Coll Cardiol 1988;11:178A.
Saksena S, An HL, Pantopoulos D: Rapid transvenous cardioversion of sustained ventricular tachycardia by programmable implantable cardioverters/defibrillators. J Am Coll Cardiol 1988;11:209A.
Saksena S, An HL, Marcantuono D, Janssen M, Osypka P: Pulsed radiofrequency ablation with conventional electrode catheter: Experimental studies and early clinical observations. PACE 1988;11:489.
An HL, Saksena S, Pantopoulos D: Prospective comparison of combined transvenous catheter and cutaneous electrodes with catheter electrodes alone for ventricular tachycardia cardioversion. PACE 1988;11:492.
Saksena S, Heselmeyer T, Batsford W, Morse DP, Porterfield JG, Gessman L, Pantopoulos D,Marcantuono D, Rosenfeld LE, McPherson CA, Elefteriades J, White M, Raman S, Serbent R: Long-term clinical experience with a versatile antitachycardia pacemaker for tachycardia termination, induction and monitoring. A multicenter study. PACE 1988;11:493.
Saksena S, Gielchinsky I: Intraoperative selection of laser ablation site in patients with sustained ventricular tachycardia. PACE 1988;11:528.
Saksena S: Improved nonepicardial electrode systems for implantable cardioverter/defibrillators. PACE 1988;11:882.
Moser S, Troup P, Saksena S, Parsonnet V, Furman S, Fisher J, Thomas A: Non-thoracotomy implantable defibrillator system. PACE 1988;11:887.
Saksena S: Catheter ablation of tachycardias with laser energy: Issues and answers. PACE 1988;11:906.
Gielchinsky I, Saksena S, Kaushik R, Alizadeh J, Pantopoulos D: Results of intraoperative laser ablation of malignant ventricular and supraventricular tachycardias. PACE 1988;11:935.
Saksena S: New techniques of the automatic implantable defibrillator. Presented, Intl Symp on Ventricular Tachyarrhythmias, Hanover, FRG, 1988.
Saksena S, Tullo N, Parsonnet V, Giechinsky I, Karanam R: Initial clinical experience with an implantable cardioverter-defibrillator using a nonepicardial electrode system. Circulation 1988;78:II-220.
1989
Saksena S, Gielchinsky I, Tullo NG: Electrophysiologic effects of argon laser irradiation during intraoperative atrioventricular node or accessory pathway ablation in man. J Am Coll Cardiol 1989;13:169A.
An H, Saksena S: Comparative effects of radiofrequency and laser ablation in normal and diseased ventricular myocardium. J Am Coll Cardiol 1989;13:175A.
Freedman RA, Fuller MS, Steinberg JD, for the ESVEM Investigators: Effect of antiarrhythmic drugs on frequency-domain parameters of signal-averaged ECG. J Am Coll Cardiol 1989;13:191A.
Saksena S, Tullo NG, Krol RB, Parsonnet V, Gielchinsky I, Karanam R: Clinical evaluation of an implantable cardioverter/defibrillator with nonepicardial leads in patients with refractory ventricular tachyarrhythmias. J Am Coll Cardiol 1989;13:215A.
An H, Saksena S: Optimal catheter electrode dimensions for non-thoracotomy
cardioversion/defibrillation lead systems. J Am Coll Cardiol 1989;13:216A.
Krol RB, Saksena S, Tullo NG, An H: Electrode configuration for optimal defibrillation with nonepicardial lead systems for cardioverter/defibrillators. PACE 1989;12(I):646.
Saksena S, Scott S, Accorti P, Boveja B, Callaghan F, Abels D: Improved pacing and internal defibrillation using a porous electrode catheter with biphasic unidirectional and bidirectional shocks. PACE 1989;12(I):663.
An H, Saksena S: Optimal location of patch electrode for non-thoracotomy cardioversion/defibrillation lead systems. PACE 1989;12(I):681.
Saksena S, Gielchinsky I, Tullo NG, Krol RB: Intraoperative map-guided argon laser ablation for refractory supraventricular and ventricular tachycardia: A three year experience. PACE 1989;12(I):687.
Saksena S, Krol RB, Tullo NG, Mauro AM: Intraoperative and postoperative evaluation of nonepicardial lead systems for implantable cardioverter/defibrillators. PACE 1989;12(I):687.
154. Anastasiou-Nana MI, Anderson JL, Gilbert EM, Miller RH, Singh S, Freedman RA, Somberg JC, Saksena S, Urquilla PR: Suppression of chronic ventricular arrhythmias with sotalol: Final report of a multicenter randomized double-blind, placebo-controlled trial. Circulation 1989;80:II-641.
1990
Saksena S, Castle L, Fogoros R, Alpert B, Kron J, Pacifico A, Griffin J, Ruskin J, Kehoe R, Yee R, Dorian P, Kerr C, Luceri R, Sakun V, Guardian Investigators: Initial clinical experience with second generation implantable defibrillator. J Am Coll Cardiol 1990;15:55A.
An H, Saksena S, Mehra R, Tullo N, Krol R, Smits K: Effect of right ventricular cathode configuration on endocardial cardioversion and defibrillation with dual electrode systems and monophasic shocks. PACE 1990;13:511.
Saksena S, Makhija V, Tullo N, Krol R, Brown J, Gielchinsky I, Saxena A, Karanam R: Device activation and clinical outcome of patients with implantable cardioverter/defibrillators for ventricular tachyarrhythmias. PACE 1990;13:528.
Krol R, Saksena S, Tullo N, Karanam R, Gielchinsky I, Saxena A, Holwitt K, Lipsius M: Clinical experience with bipolar epicardial sensing for a combined implantable pacemaker-defibrillator. PACE 1990;13:536.
Tullo N, Saksena S, Krol R, Mauro AM: Sensing characteristics of endocardial lead systems for implantable defibrillators. PACE 1990;13:546.
Saksena S, Accorti P, Scott S, Abels D, Boveja B, Callaghan F: Endocardial defibrillation with biphasic shocks using porous leads. Clin Res 1990;38:502A.
Saksena S, Castle L, Fogoros R, Alpert B, Kron J, Pacifico A, Griffin J, Ruskin J, Kehoe R, Luceri R, Yee R, Dorian P, Kerr C, Sakun V: Use of programmability with the Guardian implantable defibrillator. Rev Eur Tec Bio 1990;12:111.
162. Puchferran R, Castle L, Saksena S, Fogoros R, Alpert B, Kron J, Pacifico A, Griffin J, Ruskin J, Kehoe R, Luceri R, Yee R, Dorian P, Kerr C: Chronic electrophysiology study experience with the Guardian implantable defibrillator. Rev Eur Tec Bio 1990;12:111.
Castle L, Saksena S, Fogoros R, Alpert B, Kron J, Pacifico A, Griffin J, Ruskin J, Kehoe R, Luceri R, Yee R, Dorian P, Kerr C, Sakun V, Guardian Investigators: Initial experience with second generation implantable defibrillator. Rev Eur Tec Bio 1990;12:112.
Saksena S, Makhija V, Tullo N, Krol R, Brown J, Gielchinsky I, Saxena A, Karanam R: Device activation and clinical outcome of patients with implantable cardioverter/defibrillators. Rev Eur Tec Bio 1990;12:114.
Saksena S, Luceri R, Tullo N, Krol R, Braunstein S, Accorti P, Scott S, Singh S, Burkhardt E, Brewer G, Callaghan F: Initial clinical experience with a second generation endocardial lead system for implantable cardioverter-defibrillators. Rev Eur Tec Bio 1990;12:114.
166. An H, Saksena S, Mehra R, Tullo N, Krol R, Smits K: Effect of right ventricular cathode configuration on endocardial cardioversion and defibrillation. Rev Eur Tec Bio 1990;12:114.
Saksena S, Accorti P, Scott S, Abels D, Boveja B, Callaghan F: Endocardial defibrillation with biphasic shocks using porous leads: Effect of electrode materials and configuration. Rev Eur Tec Bio 1990;12:121.
Saksena S, An H, Mehra R, Tullo N, Krol R, Smits K: Energy delivery during endocardial cardioversion and defibrillation of ventricular tachyarrhythmias in man. Rev Eur Tec Bio 1990;12:126.
Saksena S, An H, Krol R, Tullo N: Modification of atrioventricular conduction after direct current catheter ablation. Rev Eur Tec Bio 1990;12:147.
An H, Saksena S: A comparison of radiofrequency and laser catheter ablation. Rev Eur Tec Bio 1990;12:148.
An H, Saksena S, Tullo N, Krol R: Arcing during radiofrequency ablation of supraventricular tachyarrhythmias. Rev Eur Tec Bio 1990;12:148.
Saksena S, Luceri R, Tullo NG, Krol RB, Brownstein S, Singh S, Accorti P, Brewer G, Scott S, Burkhardt E, Callaghan F: Clinical efficacy and safety of a braided endocardial pacing and defibrillator lead system for ventricular tachycardia and ventricular fibrillation using monophasic and biphasic shocks. Circulation 1990;82:III-166.
173. Saksena S, Krol RB, Tullo NG, Gielchinsky I, Saxena A, Burkhardt E: Endocardial and epicardial diastolic electrical activation patterns during sustained ventricular tachycardia. Circulation 1990;82:III- 474.
Greenberg GM, Dustman TJ, Fuller MS, Lux RL, Anderson KP, and the ESVEM Investigators: Initiation of spontaneous sustained monomorphic ventricular tachycardia. Circulation 1990;82:III-580.
1991
175. Tullo NG, Saksena S, Krol RB, Singh S, Burkhardt E, Hibbard D: Sensing characteristics of first- and second-generation endocardial (non-thoracotomy) lead systems for implantable cardioverter-defibrillators. J Am Coll Cardiol 1991;17:54A.
An H, Saksena S, Tullo NG, Krol RB, Burkhardt E, Mehra R, DeGroot P: Comparison of epicardial and endocardial lead systems for an implantable third-generation hybrid cardioverter-defibrillator. J Am Coll Cardiol 1991;17:55A.
Krol RB, Saksena S, Tullo NG, Singh S, Saxena A, Karanam R, Gielchinsky I, Burkhardt E, Gordon M, Hibbard D: Optimal pacing and sensing lead systems for implantable hybrid pacemaker-cardioverter-defibrillators. J Am Coll Cardiol 1991;17:55A.
Krol RB, Saksena S, Tullo NG, Saxena A, Suri RS, Gordon M, Burkhardt E, Hibbard D, Neglia J: Clinical efficacy of antitachycardia pacing in patients with ventricular tachyarrhythmias with implanted third-generation cardioverter-defibrillators. J Am Coll Cardiol 1991;17:86A.
Saksena S, Krol RB, Tullo NG, Gielchinsky I: Long-term outcome of laser ablation alone or in combination with endocardial resection in ventricular tachycardia. J Am Coll Cardiol 1991;17:225A.
Saksena S, Castle L, Fogoros R, Alpert B, Kron J, Pacifico A, Griffin J, Ruskin J, Kehoe R, Yee R, Dorian P, Kerr C, Luceri R, Poczobutt-Johanas M, Poliseno M, for Guardian Investigators Group & Telectronics Pacing Systems: Multicenter clinical investigation of a second generation programmable pacemaker-cardioverter-defibrillator. J Am Coll Cardiol 1991;17:344A.
Saksena S, Krol RB, Tullo NG, Makhija V, Kunecz D, Gordon M: Patterns of device activation for multi-programmable and non-programmable implantable cardioverter-defibrillators. J Am Coll Cardiol 1991;17:344A.
Ellenbogen K, Welch W, Luceri R, Jackman W, Singer I, Dorian P, Saksena S, Brachman J, Renker M, and Phase I: Clinical evaluation of the Guardian ATP 4210 implantable pacemaker/defibrillator: Worldwide experience. PACE 1991;14(II):623.
Hamill S, Stanton M, Packer D, and the PCD Investigator Group: The effect of therapy type (autodecremental, burst, cardioversion) on subsequent ventricular tachycardia cycle length in patients with an implantable antitachycardia pacing-cardioversion-defibrillation device. PACE 1991;14(II):623.
Wilber DJ, Poczobutt-Johanas, and the Guardian Clinical Investigators: Time-dependent sensing alterations in implantable defibrillators: Lessons from the Telectronics Guardian 4202/4203. PACE 1991;14(II):624.
Saksena S, An H, Krol RB, Burkhardt E: Simultaneous biphasic shocks enhance efficacy of endocardial cardioversion-defibrillation in man. PACE 1991;14(II):624.
Saksena S, Ward D, Krol RB, Camm AJ: Efficacy of braided endocardial defibrillation leads: Acute testing and chronic implant. PACE 1991;14(II):719.
Markham J, Mehta D, Marchese T, Pacetti P, Saksena S, Haffajee C: Predictors of success and initial human experience with nonthoracotomy implantation of a permanent pacer-cardioverter-defibrillator device. PACE 1991;14(II):722.
The ESVEM Investigators: Determinants of a drug efficacy prediction in the ESVEM trial: Differences between electrophysiological study (EPS) and Holter monitoring (HM). Circulation 1991;84:II-348.
Mason JW and The ESVEM Investigators: Unsustained VT as a predictor of spontaneous sustained VT in the ESVEM study. Circulation 1991;84:II-348.
Ellenbogen K, Luceri R, Dorian P, Brachman J, Uther J, Beckman K, Singer I, Zipes D, Saksena S, Estes M, Franklin J, and Phase I Clinical Investigators: Clinical evaluation of implantable cardioverter defibrillator (CD) function: Importance of data logging to assess device efficacy. Circulation 1991;84:II-426.
Saksena S, Luceri R, Krol RB, Accorti P, Brewer G, Scott S, Burkhardt E, Callaghan F: Endocardial cardioversion-defibrillation using braided endocardial leads and simultaneous biphasic shocks. Circulation 1991;84:II-610.