The Electrophysiology Research Foundation is a charitable organization incorporated on August 2, 1982. The Foundation is a non-profit corporation, organized and operated exclusively for charitable purposes.

CURRENT TRIALS:

Reanalysis of the AFFIRM trial:

Saksena S, Slee A, Waldo AL, Freemantle N, Reynolds M, Rosenberg Y, Rathod S, Grant S, Thomas E, Wyse DG: Cardiovascular Outcomes in the AFFIRM Trial (Atrial Fibrillation Follow-Up Investigation of Rhythm Management): An Assessment of Individual Antiarrhythmic Drug Therapies Compared With Rate Control With Propensity Score-Matched Analyses. J Am Coll Cardiol 2011;58:1975–85
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Saksena S, Sra J, Jordaens L, Kusumoto F, Knight B, Natale A, Kocheril A, Nanda N, Nagarakanti R, Simon A, Viggiano M, Lokhandwala T, Chandler M for the ICE CHIP Investigator Study Group: A Prospective Comparison of Cardiac Imaging Using Intracardiac Echocardiography with Trans- Esophageal Echocardiography in Patients with Atrial Fibrillation: The Intra-Cardiac Echocardiography guided Cardioversion Helps Interventional Procedures (ICE-CHIP) study; Circulation Arrhythmias Electrophysiol. 2010: Dec 1;3(6):571
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Current Trials:

TOPCAT

Aldosterone antagonist in Heart Failure with Preserved Ejection Fraction – Sponsor: National Heart Lung and Blood Institute, Bethesda, MD

SHIELD

Azimilide to Reduce Implantable Defibrillator Shock Therapy – Sponsor : Forest Research Institute, New York, NY

EMERALD

Long term outcomes of Dual chamber Pacemakers – Sponspor: Sorin, Italy

2006

226. Saksena S: Real time online imaging for interventional electrophysiologists: Many directions an extraordinary opportunities.J Interv Card Electrophysiol. 2006 Jan;15(1):5-8.
227. Saksena S: Atrial fibrillation: is the fog lifting? J Interv Card Electrophysiol. 2006 Mar;15(2):75-8.
228. Saksena S: Gerard M. Guiraudon: a pioneer in surgery for tachycardias. J Interv Card Electrophysiol. 2006 Apr;15(3):205-6.
229. Saksena S: Achieving global access to heart rhythm therapies in the next decade: a tangible goal. J Interv Card Electrophysiol. 2006 Dec;17(3):163-8

2007

230. Saksena S: The journal in 2007: Defining new frontiers. J Interv Card Electrophysiol. 2006 Sep;16(3):139-40
231. Rao HB, Saksena S: Impact of “Hybrid therapy” on Long – Term Rhythm Control and Arrhythmia Related Hospitalizations in patients with drug-refractory persistent and permanent Atrial Fibrillation. J. Intervent. Card. Electrophysiol. J Interv Card Electrophysiol. 2007 Mar;18(2):127-36. Epub 2007 Mar 20
232. Saksena S, Hettrick D, Koehler J, Grammatico A, Padeletti L: Progression of paroxysmal atrial fibrillation to persistent atrial fibrillation in patients with bradyarrhythmias. Am Heart J. 2007 Nov;154(5):884-92. Epub 2007 Sep 14
233. Saksena S: Achieving Global Access to Heart Rhythm Therapies in the Next Decade: A tangible goal; J Interv Card Electrophysiol. 2006 Dec;17(3):163-8

2008

234. Saksena S, Nagarakanti R.:The future of Implantable Defibrilator and Cardiac Resynchronization Therapy Trials. J Interv Card Electrophysiol. 2008 Oct;23(1):29-39. Epub 2008 Aug 29
235. Lewalter T, Saksena S.:Interventional Electrophysiology: New Frontiers for an Ever Expanding Discipline. J Interv Card Electrophysiol. 2008 Aug;22(2):85-6
236. HEART Group: A Statement on Ethics from the Heart Group; 2008Jun;21(3):279-81

2009

237. Saksena S: Evidence Based Medicine and Atrial Fibrillation Ablation: 2009 and the view beyond. J Intervent Card Electrophysiol; 2009:24:1-3
238. Skadsberg N, Nagarakanti R, Saksena S: Biatrial, 3-Dimensional Mapping of Human Atrial Fibrillation: Methodology and Clinical Observations. J of AFib, published online April 2009
239. Saksena S, Simon A, Mathew P, Nagarakanti R: Intracardiac Echocardiography Guided Cardiac Resynchronization Therapy: Technique and Clinical Application;PACE 2009: 32(8):1030-9
240. Costantini O, Hohnloser S, Kirk M, Lerman B, Baker J, Sethuraman B, Dettmer M, Rosenbaum D, the ABCD Trial Investigators. The ABCD (Alternans Before Cardioverter Defibrillator) Trial: Strategies Using T-Wave Alternans to Improve Efficiency of Sudden Cardiac Death Prevention JACC; 2009: 53:471-9
241. Lau CP, Wang CC, Ngarmukos T, Kim YH, Kong CW, Omar R, Sriratanasathavorn C, Munawar M, Kam R, Lee KL, Lau EO, Tse HF; SAFE Study Steering Committee for SAFE Study Group: A Prospective Randomized Study to Assess the Efficacy of Rate and Site of Atrial Pacing on Long-Term Development of Atrial Fibrillation. J Cardiovasc Electrophysiol. 2009 Sep;20(9):1020-5

2010

242.Saksena S:A truly new view from the summit: from translational science to outcomes research in clinical arrhythmology. J Interv Card Electrophysiol. 2010 Jan;27(1):1-2
243.Saksena S, Sra J, Jordaens L, Kusumoto F, Knight B, Natale A, Kocheril A, Nanda N, Nagarakanti R, Simon A, Viggiano M, Lokhandwala T, Chandler M for the ICE CHIP Investigator Study Group: A Prospective Comparison of Cardiac Imaging Using Intracardiac Echocardiography with Trans-Esophageal Echocardiography in Patients with Atrial Fibrillation: The Intra-Cardiac Echocardiography guided Cardioversion Helps Interventional Procedures (ICE-CHIP) study; Circulation Arrhythmias Electrophysiol. 2010: Dec 1;3(6):571-7

2011

337. Saksena S.Twenty-five years of implantable defibrillator practice in the USA: are we ready for globalization?J Interv Card Electrophysiol. 2011 Jan;30(1):1-3
338. Saksena S, Lewalter T, Luderitz B:Twenty years of interventional cardiac electrophysiology: Meeting future challenges with continuing innovations.J Interv Card Electrophysiol. 2011 Jun;31(1):1-2.
339. Nagarakanti R, Saksena S, Hettrick D, Koehler JL, Grammatico A, Padeletti L.Progression of new onset to established persistent atrial fibrillation: an implantable device-based analysis with implications for clinical classification of persistent atrial fibrillation.J Interv Card Electrophysiol. 2011 Oct;32(1):7-15
340. Saksena S, Slee A, Waldo AL, Freemantle N, Reynolds M, Rosenberg Y, Rathod S, Grant S, Thomas E, Wyse DG: Cardiovascular Outcomes in the AFFIRM Trial (Atrial Fibrillation Follow-Up Investigation of Rhythm Management): An Assessment of Individual Antiarrhythmic Drug Therapies Compared With Rate Control With Propensity Score-Matched Analyses. J Am Coll Cardiol 2011;58:1975–85

2012

341. Saksena S: Clinical trials of antiarrhythmic therapies and optimizing health care resource deployment: the need for a paradigm shift. J Interv Card Electrophysiol. 2012 Jan;33(1):1-3.